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DP IB Biology: HL

Topic Questions

Home / IB / Biology: HL / DP / Topic Questions / 8. Metabolism, Cell Respiration & Photosynthesis (HL Only) / 8.1 Metabolism / Structured Questions: Paper 2


8.1 Metabolism

Question 1a

Marks: 1
a)
The graph below shows how enzymes affect biological reactions.
energy-level-diagram-with-and-without-enzyme-sq

Use the graph and your own knowledge of enzyme function to explain how enzymes function as biological catalysts. 

[1 mark]

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    Question 1b

    Marks: 2
    b)

    The graph shows how the addition of a molecule named here as molecule X affects the rate of an enzyme-controlled reaction. 

    rate-of-reaction-with-the-addition-of-a-non-competitive-inhibitor-sq

    Describe how the addition of molecule X affects the rate of reaction in the graph.

    [2 marks]

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      Question 1c

      Marks: 2
      c)

      The image below shows how molecule X interacts with the enzyme.

      non-competitive-inhibitor-binding-to-enzyme-sq

      Use the image to explain the results shown in the graph in part (b). 

      [2 marks]

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        Key Concepts
        Enzyme Inhibitors

        Question 1d

        Marks: 1
        d)
        The image below shows another molecule, molecule Y.

        competitive-inhibitor-sq

        Suggest how molecule Y might interact with the enzyme shown in part (c).

        [1 mark]

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          Key Concepts
          Enzyme Inhibitors

          Question 1e

          Marks: 2
          e)
          Sketch a line on the graph from part (b) to show how molecule Y might affect the rate of reaction.


          [2 marks]

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            Question 2a

            Marks: 1
            a)
            Define the term 'bioinformatics'. 
            [1 mark]
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              Question 2b

              Marks: 1
              b)

              The parasite Plasmodium causes the disease malaria when injected into the human bloodstream.

              Using bioinformatics, scientists can analyse the proteome of the Plasmodium parasite to better understand its metabolic pathways including the enzymes which catalyse them.

              Define what is meant by the term proteome.  

              [1 mark]

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                Question 2c

                Marks: 3
                c)
                So far over 300,000 chemicals have been screened to identify 19 new chemicals that can be used to treat malaria. 

                Calculate the percentage chance of finding a chemical that can be used to treat malaria. 

                Give your answer in standard form.

                [3 marks]

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                  Question 3a

                  Marks: 2
                  a)
                  State, with a reason, the type of enzyme inhibition shown in the image below.q2a_8-1_metabolism_medium_ib_hl_biology_sq
                  [2 marks]
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                    Key Concepts
                    End-product Inhibition

                    Question 3b

                    Marks: 3
                    b)
                    Explain what is meant by allosteric inhibition.
                    [3 marks]
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                      Key Concepts
                      End-product Inhibition

                      Question 3c

                      Marks: 3
                      c)
                      The graph below shows the relationship between substrate concentration and rate of reaction for a normal enzyme and a competitive inhibitor.

                      q2c_8-1_metabolism_medium_ib_hl_biology_sq

                      Explain the effect competitive inhibition has on the rate of reaction.

                      [3 marks]

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                        Question 3d

                        Marks: 2
                        d)
                        State an example of a competitive and non-competitive inhibitor.
                        [2 marks]
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                          Key Concepts
                          Enzyme Inhibitors

                          Question 4a

                          Marks: 3
                          a)
                          Metabolic pathways exist in all living organisms.
                           
                          Explain what is meant by a metabolic pathway.
                          [3 marks]
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                            Key Concepts
                            Metabolic Pathways

                            Question 4b

                            Marks: 3
                            b)
                            Describe the differences between anabolism, catabolism and metabolism.
                            [3 marks]

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                              Key Concepts
                              Metabolism
                              Anabolism

                              Question 4c

                              Marks: 2
                              c)
                              Metabolic paths require enzymes. Hexose kinase is the initial enzyme needed during glycolysis, it catalyses the phosphorylation of glucose by ATP. This reaction would occur without the presence of hexose kinase.

                              Explain the role hexose kinase has in this reaction.
                              [2 marks]
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                                Question 5a

                                Marks: 7

                                One mark is available for clarity of communication throughout this question.

                                a)
                                This question is about metabolic pathways.

                                i) Describe the meaning of the term metabolic pathway.

                                [3 marks]

                                ii) Outline how end-product inhibition can act to limit a metabolic pathway.

                                [4 marks]

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                                  Key Concepts
                                  End-Product Inhibition

                                  Question 5b

                                  Marks: 4
                                  b)
                                  State some of the ways scientists can use bioinformatics to help with their research.
                                  [4 marks]
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                                    Question 5c

                                    Marks: 4
                                    c)
                                    Compare and contrast the allosteric and active sites of an enzyme.
                                    [4 marks]
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                                      Key Concepts
                                      Enzyme Inhibitors