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DP IB Biology: HL

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Home / IB / Biology: HL / DP / Topic Questions / 7. Nucleic Acids (HL Only) / 7.2 Transcription & Gene Expression / Structured Questions: Paper 2


7.2 Transcription & Gene Expression

Question 1a

Marks: 3
a)

The compact structure of a nucleosome makes it impossible for transcription of DNA to occur.

Describe the mechanism that needs to occur in order to initiate transcription.

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    Question 1b

    Marks: 1
    b)
    During transcription, the DNA strand unwinds into two strands.  One is named the sense strand and the other one the antisense strand.

    Distinguish between the sense and antisense strands of DNA during transcription.
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      Question 1c

      Marks: 2
      c)
      The diagram below shows the process of transcription.

       q1c_7-2_transcription_gene_expression_medium_ib_hl_biology_sq

         i.       Label the sense and antisense strands.

         ii.      Draw an arrow on the diagram to show where the promoter region is located.

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        Question 1d

        Marks: 1
        d)

        Transcription occurs in three stages: initiation, elongation and termination.

        Describe what events occur during the elongation stage of transcription.

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          Question 2a

          Marks: 3
          a)
          Nucleosomes help regulate transcription in eukaryotic cells.

          State three chemical modifications of a nucleosome that could alter gene expression. 
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            Question 2b

            Marks: 2
            b)
            Regulation of gene expression occurs in both eukaryotes and prokaryotes.

               Describe two differences of this process in eukaryotes and prokaryotes.

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              Question 2c

              Marks: 3
              c)
              The following sections of a gene are important in regulating gene expression and transcription: promoter, coding sequence, terminator.

                        State the role of each of these components.

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                Question 3a

                Marks: 3
                a)
                Environmental factors, internal and external, can influence gene expression by affecting levels of regulatory proteins or transcription factors. Environmental factors explain the differences observed between identical twins, even though they have the same DNA.

                Scientists have investigated a range of phenotypic traits, such as intelligence, in twins.  Data has been compared between identical and non-identical twins to help determine whether these characteristics are genetic or more greatly influenced by the environment. The graphs below shows data comparing identical and non-identical twins and their IQ.q3c_7-2_transcription_gene_expression_medium_ib_hl_biology_sq
                Suggest conclusions that could be drawn from the data shown in the graphs. 
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                  Question 3b

                  Marks: 2
                  b)
                  The scientists also investigated how many hours per night identical and non-identical twins typically sleep. The results are shown in the graph below. The scientists concluded that sleep was not a heritable factor and environmental factors caused differences in sleep time.
                  q3b_7-2_transcription_gene_expression_medium_ib_hl_biology_sq   

                  Evaluate the scientists’ conclusion.

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                    Question 3c

                    Marks: 3
                    c)
                    The environment has been shown to contribute to heritable changes in gene function. One such factor is epigenetics.

                    Outline what is meant by the epigenome.
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                      Key Concepts
                      Epigenetics

                      Question 3d

                      Marks: 2
                      d)
                      DNA methylation involves the direct addition of a methyl group (-CH3) to cytosine bases which can influence gene expression.

                                Explain the impact of methylation of DNA bases on gene expression.

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                        Question 4a

                        Marks: 3
                        a)
                        Gene expression can be regulated after an mRNA transcript has been produced, this is called post-transcriptional modification of mRNA.  

                                  Outline the mechanisms involved in post- transcriptional modification.

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                          Key Concepts
                          Modification of RNA

                          Question 4b

                          Marks: 2
                          b)
                          The diagram below shows the base sequence on part of a template DNA strand.
                          q4b_7-2_transcription_gene_expression_medium_ib_hl_biology_sq

                          Deduce, with a reason, the sequence of bases on the mRNA transcribed from this strand.
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                            Key Concepts
                            Modification of RNA

                            Question 4c

                            Marks: 1
                            c)
                            Mature mRNA is transcribed from a gene and then translated into a protein. One single gene can give rise to different polypeptide chains. 

                            Explain how a single gene can give rise to different amino acid sequences.
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                              Key Concepts
                              mRNA Splicing

                              Question 4d

                              Marks: 1
                              d)
                              A piece of mRNA is 972 nucleotides long but the DNA coding strand from which it was transcribed is 1215 nucleotides long.

                              Explain why there is a difference in the number of nucleotides.

                               

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                                Key Concepts
                                mRNA Splicing

                                Question 5a

                                Marks: 7

                                One mark is available for clarity of communication throughout this question.

                                a)
                                Messenger RNA (mRNA) is used during translation to form polypeptides.

                                Describe how mRNA is produced in the nucleus of a cell.
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                                  Question 5b

                                  Marks: 4
                                  b)
                                  Explain the events of mRNA splicing.
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                                    Key Concepts
                                    mRNA Splicing

                                    Question 5c

                                    Marks: 4
                                    c)
                                    Outline the role of protein-protein interactions in the regulation of transcription.
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