DP Chemistry Questionbank

Dose response curves are determined for each drug.

Outline the significance of range “a”.

Suggest one ethical consideration faced by medical researchers when developing medications.

Compare, giving a reason, the bioavailability of soluble aspirin with aspirin.

Consider the following antacids:

Show that antacid X is more effective, per tablet, than antacid Y.

Comment on the risk of overdose when taking aspirin as an analgesic, referring to the following values, for a person weighing $70 \mathrm{kg}$:

Minimum therapeutic dose $=0.5 \mathrm{g}$

Estimated minimum lethal dose $=15 \mathrm{g}$

Comment on the risk of overdose when taking aspirin as an analgesic, referring to the following values, for a person weighing $70 \mathrm{kg}$:

Minimum therapeutic dose $=0.5 \mathrm{g}$

Estimated minimum lethal dose $=15 \mathrm{g}$

Outline the difference between the therapeutic index in animal studies and the therapeutic index in humans.

State what is meant by the bioavailability of a drug.

Drug testing is necessary to determine safe and effective doses.

Distinguish between the lethal dose (LD₅₀) and the toxic dose (TD₅₀).

Suggest a reason for using a phosphate salt of oseltamivir in oral tablets.

Distinguish between therapeutic window and therapeutic index in humans.

Therapeutic window:

Therapeutic index:

Suggest a reason for using a phosphate salt of oseltamivir in oral tablets.

Distinguish between therapeutic window and therapeutic index in humans. 

Therapeutic window:

Therapeutic index: