| Date | November 2017 | Marks available | 1 | Reference code | 17N.3.sl.TZ0.18 |
| Level | SL | Paper | 3 | Time zone | TZ0 |
| Command term | Outline | Question number | 18 | Adapted from | N/A |
Question
New drugs undergo thorough clinical trials before they are approved.
Outline the difference between the therapeutic index in animal studies and the therapeutic index in humans.
State the method of drug administration that gives the maximum bioavailability.
Markscheme
in animal studies AND in humans
OR
in animal studies lethal dose/LD50 AND in humans toxic dose/TD50
intravenous/IV «injection»
OR
injection into the bloodstream
Examiners report
Syllabus sections
- 17N.3.sl.TZ0.18b: State the method of drug administration that gives the maximum bioavailability.
-
17M.3.sl.TZ2.15b.ii:
Compare, giving a reason, the bioavailability of soluble aspirin with aspirin.
-
20N.3.sl.TZ0.12:
Consider the following antacids:
Show that antacid X is more effective, per tablet, than antacid Y.
- 18N.3.sl.TZ0.12a: State the internal bond angles in the β-lactam ring and the expected bond angles for the same...
- 18N.3.sl.TZ0.13c: Outline the meaning of the bioavailability of a drug.
- 18N.3.hl.TZ0.17b: Outline the meaning of the bioavailability of a drug.
-
18M.3.sl.TZ2.15:
Drug testing is necessary to determine safe and effective doses.
Distinguish between the lethal dose (LD50) and the toxic dose (TD50).
-
19M.3.hl.TZ1.22b:
Suggest a reason for using a phosphate salt of oseltamivir in oral tablets.
-
19M.3.sl.TZ1.17a(ii):
Suggest a reason for using a phosphate salt of oseltamivir in oral tablets.
-
17M.3.sl.TZ2.18b:
Suggest one ethical consideration faced by medical researchers when developing medications.
- 19N.3.hl.TZ0.21b: Experimental research on both animals and humans contributes to the development...
-
18M.3.sl.TZ1.13b.i:
State what is meant by the bioavailability of a drug.
-
19M.3.hl.TZ2.21a:
Distinguish between therapeutic window and therapeutic index in humans.
Therapeutic window:
Therapeutic index:
-
17M.3.sl.TZ1.18a:
Dose response curves are determined for each drug.
Outline the significance of range “a”.
-
19M.3.sl.TZ2.14a:
Distinguish between therapeutic window and therapeutic index in humans.
Therapeutic window:
Therapeutic index:
-
20N.3.sl.TZ0.11d:
Comment on the risk of overdose when taking aspirin as an analgesic, referring to the following values, for a person weighing :
Minimum therapeutic dose
Estimated minimum lethal dose
-
20N.3.hl.TZ0.15d:
Comment on the risk of overdose when taking aspirin as an analgesic, referring to the following values, for a person weighing :
Minimum therapeutic dose
Estimated minimum lethal dose
