The efficiency of a drug depends on the polarity of its molecule. Explain how the polarity of a drug can be modified in order to increase its solubility in water and how it affects the distribution of the drug around the body.

(non-charged) carboxylic acids/groups can be converted into more polar salts/carboxylates;

(non-charged) amines/amino groups can be converted into more polar amines/ammonium groups;

more polar/charged/ionic substances are more soluble in water/concentrate in the bloodstream;

Most candidates stated that polar drugs are more soluble in blood, and some suggested turning the drugs into a salt but didn‟t describe how. Most also had a pretty clear understanding of THC and its effects.