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Date November 2009 Marks available 2 Reference code 09N.3.sl.TZ0.D2
Level SL Paper 3 Time zone TZ0
Command term Explain and State Question number D2 Adapted from N/A

Question

Explain the meaning of the terms:

The effectiveness of a drug depends on the method of administration.

side-effect

[1]
a.i.

therapeutic window

[1]
a.ii.

One method of injecting drugs into the body results in the drug having a very rapid effect. State the method and explain its rapid action.

[2]
b.i.

List the two other methods which can be used to inject drugs into the body.

[1]
b.ii.

Identify the method of administration used to treat respiratory diseases such as asthma.

[1]
b.iii.

Markscheme

an effect produced in addition to the one intended / unwanted/undesired effect;

a.i.

range of a drugs concentration (in blood) between effective/\({\text{E}}{{\text{D}}_{{\text{50}}}}\) and toxic levels/\({\text{L}}{{\text{D}}_{{\text{50}}}}\) / (Therapeutic Index) = \({\text{L}}{{\text{D}}_{{\text{50}}}}\) / \({\text{E}}{{\text{D}}_{{\text{50}}}}\);

Do not accept “difference of drug concentration”.

a.ii.

intravenous / into veins;

transported/pumped via blood (to various parts of body);

b.i.

intramuscular/intermuscular/into muscles and subcutaneous/into fat;

Allow [1] if all three methods are stated in (b) (i) and (ii) but not in correct place.

b.ii.

inhalation/breathing it in;

b.iii.

Examiners report

This was generally very well answered, with no serious errors.

a.i.

This was generally very well answered, with no serious errors.

a.ii.

This was generally very well answered, with no serious errors.

b.i.

This was generally very well answered, with no serious errors.

b.ii.

This was generally very well answered, with no serious errors.

b.iii.

Syllabus sections

Options » D: Medicinal chemistry » D.1 Pharmaceutical products and drug action
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