| Date | November 2017 | Marks available | 1 | Reference code | 17N.3.sl.TZ0.18 |
| Level | SL | Paper | 3 | Time zone | TZ0 |
| Command term | Outline | Question number | 18 | Adapted from | N/A |
Question
New drugs undergo thorough clinical trials before they are approved.
Outline the difference between the therapeutic index in animal studies and the therapeutic index in humans.
[1]
a.
State the method of drug administration that gives the maximum bioavailability.
[1]
b.
Markscheme
in animal studies \(\frac{{{\text{LD50}}}}{{{\text{ED50}}}}\) AND in humans \(\frac{{{\text{TD50}}}}{{{\text{ED50}}}}\)
OR
in animal studies lethal dose/LD50 AND in humans toxic dose/TD50
a.
intravenous/IV «injection»
OR
injection into the bloodstream
b.
Examiners report
[N/A]
a.
[N/A]
b.
