DP Biology Questionbank

• Syllabus

Option B: Biotechnology and bioinformatics (Additional higher level topics)

Sub sections and their related questions

B.4 Medicine

• 15M.3.SL.TZ2.17a: Outline how a defective gene can be replaced using viral vectors.
• 15M.3.HL.TZ1.7a: Identify the age and ethnic group of the individual with the highest diversity of gut bacterial...
• 15M.3.HL.TZ1.7b (i): Outline the trends in the number of bacterial species in the digestive tracts of Amerindians.
• 15M.3.HL.TZ1.7b (ii): Distinguish between the trends seen in the three populations.
• 15M.3.HL.TZ1.7c: Suggest two reasons for how the different environments of the three human populations affect the...
• 15M.3.HL.TZ1.7d: A century ago, it was discovered that each person belonged to one of four blood types.  Now some...
• 15M.3.SL.TZ1.18c: Identify one risk associated with gene therapy.
• 15M.3.HL.TZ2.8a: Outline how a defective gene can be replaced using viral vectors.
• 15N.3.SL.TZ0.16a: State the percentage of P. aeruginosa that were resistant to fluoroquinolone in 1996.
• 15N.3.SL.TZ0.16b: Compare the trends in fluoroquinolone use and resistance to fluoroquinolone in other...
• 15N.3.SL.TZ0.16c: Predict the results if data from the same hospitals were collected for P. aeruginosa resistance...
• 15N.3.SL.TZ0.16d: Discuss the implications of the data in the graph for the health of patients.
• 15N.3.SL.TZ0.18b: Researchers are studying several ways to treat cancer using gene therapy. Discuss the risks of...
• 13M.3.SL.TZ2.17c: Discuss the possible consequences of gene therapy.
• 11M.3.SL.TZ1.18c: Discuss the risks of gene therapy.
• 11M.3.SL.TZ2.17a: Describe the use of viral vectors in gene therapy.
• 12M.3.SL.TZ1.18a: Gene therapy is a new technology which can be used to treat hereditary diseases. Outline two...
• 10M.3.HL.TZ1.9: Discuss methods used in gene therapy, including the risks involved.
• 10M.3.SL.TZ2.18a: Gene therapy may offer cures for inherited diseases and, perhaps, improve quality of life....
• 10M.3.SL.TZ2.18b: Discuss risks of gene therapy.
• 11N.3.HL.TZ0.9: Discuss the use of viral vectors in gene therapy including the risks involved.
• 11N.3.SL.TZ0.17b: Outline the use of viral vectors in gene therapy.
• 09N.3.HL.TZ0.9: Discuss the risks of gene therapy including safety, conflict of interest and ethical arguments.
• 09N.3.SL.TZ0.17b: Outline the use of viral vectors in gene therapy.
• 16M.3.HL.TZ0.13: Explain how infection by a pathogen can be detected by an ELISA test for antigens.
• 16N.3.HL.TZ0.11a: Metabolites that indicate disease can be detected in urine. State a metabolite found in urine and...
• 16N.3.HL.TZ0.11b: Discuss the implications of biopharming using a specific example.
• 17M.2.HL.TZ1.1f.ii: Suggest a reason for the greater expression of the gene for the urea transporter after an...
• 17M.3.SL.TZ1.16a: Calculate the diversity of site C. Working should be shown.
• 17M.3.HL.TZ1.11a.i: Outline what is meant by the term genetic markers.
• 17M.3.HL.TZ1.11a.ii: Outline two uses of genetic markers.
• 17M.3.HL.TZ1.11b: Evaluate the use of viral vectors in gene therapy.
• 17M.3.HL.TZ1.11c: Outline the use of microarrays to test for genetic disease.
• 17M.3.HL.TZ2.12a: Outline one way in which genetic sequences can be used to indicate predisposition to a disease.
• 17M.3.HL.TZ2.12b: Outline the use of luminescent probes in the treatment of tumours.
• 17N.3.HL.TZ0.10d: Outline possible medical applications of the polymerase chain reaction (PCR).
• 17N.3.HL.TZ0.13: Discuss biopharming.

B.5 Bioinformatics

• 16M.3.HL.TZ0.12a: Using the data in the cladogram, state the reason for sale of Sample 1 meat being illegal in Japan.
• 16M.3.HL.TZ0.12b: Using the data in the cladogram, state the reason for sale of Sample 4 meat being illegal in Japan.
• 16M.3.HL.TZ0.12c: Outline how the polymerase chain reaction (PCR) might have been used in this study.
• 16M.3.HL.TZ0.12d: Explain how sequence alignment software might have been used in this study.
• 16N.3.HL.TZ0.12a: State the bioinformatics tool used to obtain the alignment.
• 16N.3.HL.TZ0.12b: State the meaning of the dash (–) in the alignment.
• 16N.3.HL.TZ0.12c: (i) Identify the longest amino acid sequence where there are no differences amongst the five...
• 16N.3.HL.TZ0.12d: Describe briefly how the cladogram was obtained.
• 16N.3.HL.TZ0.12e: Determine which two genera are most closely related according to their cytochrome c protein...
• 17M.2.HL.TZ1.1f.ii: Suggest a reason for the greater expression of the gene for the urea transporter after an...
• 17M.3.SL.TZ1.16a: Calculate the diversity of site C. Working should be shown.
• 17M.3.HL.TZ1.9b: Explain what the branching off points represent in the cladogram of these fungi.
• 17M.3.HL.TZ1.12: Explain how BLAST searches are carried out and the applications of different types of these...
• 17N.3.HL.TZ0.10a: Identify the species that has the lowest percentage of coding sequences.
• 17N.3.HL.TZ0.10b: State how similar nucleotide sequences can be identified.
• 17N.3.HL.TZ0.10c: The yeast Saccharomyces cerevisiae was the first eukaryotic organism to have its entire genome...