Explain how an increase in cell respiration in a tissue causes increased release of oxygen by hemoglobin in the tissue.

a. cell respiration consumes O₂ / lowers O₂ partial pressure in tissues

b. (actively) respiring tissues release CO₂ / partial pressure of CO₂ increases 

c. CO₂ increases acidity / lowers pH of the blood 

d. decreases hemoglobin’s affinity for O₂ 

e. promotes the release of oxygen to respiring cells/tissues 

f. binding of hydrogen ions/ allosteric effect / conformational change in hemoglobin releases O₂ more readily 

g. more oxygen released at the same partial pressure 

h. this shifts the oxygen dissociation curve to the right/Bohr shift

These points can be presented in a graph.

diagram with correct labels:

i. partial pressure O₂ on x-axis and (percentage) saturation hemoglobin with O₂ on y-axis 

j. exponential shape curve at lower partial pressure/concentration of O₂ 

k. curve shifted to right (and lower) for higher partial pressure /concentration of CO₂ /lower pH