| Date | May 2013 | Marks available | 3 | Reference code | 13M.3.SL.TZ1.15 |
| Level | Standard level | Paper | Paper 3 | Time zone | Time zone 1 |
| Command term | Explain | Question number | 15 | Adapted from | N/A |
Question
The diagram below shows a synapse where the neurotransmitter is dopamine and some of the processes that take place during nerve transmission.
Explain the effect of cocaine on neurotransmission at a synapse.
Markscheme
a. dopamine initiates depolarization of post-synaptic membrane;
b. cocaine binds to (transporter) carrier proteins/proteins in pre-synaptic membrane;
c. cocaine blocks reabsorption (of dopamine);
d. cocaine causes dopamine build up in synaptic cleft/space;
e. so stimulus continues/cocaine is excitatory;
Examiners report
Most candidates were able to explain the effect of cocaine at synapses.
Syllabus sections
Option A: Neurobiology and behaviour » Option A: Neurobiology and behaviour (Additional higher level topics) » A.5 Neuropharmacology
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