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Date May 2019 Marks available 2 Reference code 19M.3.hl.TZ2.26
Level HL Paper 3 Time zone TZ2
Command term Calculate Question number 26 Adapted from N/A

Question

Technetium-99m, Tc-99m, is a gamma-ray emitter commonly used as a medical tracer.

Its half-life is 6.0 hours.

Evaluate the suitability of technetium-99m for this use.

[2]
a.

Calculate the percentage of technetium-99m remaining after 10.0 hours. Use section 1 of the data booklet.

[2]
b.

Markscheme

Any two of:
can be readily “tagged” to variety of biologically active carriers «which will deliver it to specific locations for imaging uses»  [✔]

frequency of radiation is compatible with existing X-ray detection apparatus [✔]

product of decay has low radioactivity/relatively short half-life/low total exposure to patient [✔]

«but small» increased risk of cancer to patient [✔]

must be made on site [✔]

 

Note: Accept other valid answers outlining advantages or limitations of Tc-99m, such as “produces only LLW”, “Tc is a transition element forming compounds in a variety of oxidation states”, “gamma-radiation «can escape the body and» be detected by external sensors”, “activity decreases quickly, so dose must be calculated prior to each injection”.

a.

ALTERNATIVE 1

N ( t ) N 0 = ( 1 2 ) 10 6.0   [✔]
31 «% remaining» [✔]

 

ALTERNATIVE 2

λ « ln 2 t 1 2 »= 0.1155 hours–1 []

« N N 0  × 100 = eλt ×100 = 0.31498 × 100»

31 «% remaining» [✔]

 

NoteM1 is for correct substitution of values.

Award [2] for correct final answer.

 

b.

Examiners report

The most frequent response was the short half-life, followed by the emission and detection of gamma radiation.

a.

Most candidates were able to calculate the percentage of technetium-99m correctly.

b.

Syllabus sections

Options » D: Medicinal chemistry » D.8 Nuclear medicine (HL only)
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Options » D: Medicinal chemistry
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