DP Biology Questionbank
6.5 Neurons and synapses
Description
Nature of science:
Cooperation and collaboration between groups of scientists—biologists are contributing to research into memory and learning. (4.3)Understandings:
- Neurons transmit electrical impulses.
- The myelination of nerve fibres allows for saltatory conduction.
- Neurons pump sodium and potassium ions across their membranes to generate a resting potential.
- An action potential consists of depolarization and repolarization of the neuron.
- Nerve impulses are action potentials propagated along the axons of neurons.
- Propagation of nerve impulses is the result of local currents that cause each successive part of the axon to reach the threshold potential.
- Synapses are junctions between neurons and between neurons and receptor or effector cells.
- When presynaptic neurons are depolarized they release a neurotransmitter into the synapse.
- A nerve impulse is only initiated if the threshold potential is reached.
Applications and skills:
- Application: Secretion and reabsorption of acetylcholine by neurons at synapses.
- Application: Blocking of synaptic transmission at cholinergic synapses in insects by binding of neonicotinoid pesticides to acetylcholine receptors.
- Skill: Analysis of oscilloscope traces showing resting potentials and action potentials.
Guidance:
- The details of structure of different types of neuron are not needed.
- Only chemical synapses are required, not electrical, and they can simply be referred to as synapses.
Utilization:
- An understanding of the workings of neurotransmitters and synapses has led to the development of numerous pharmaceuticals for the treatment of mental disorders.
Syllabus and cross-curricular links:
Biology
Topic 1.4 Membrane transport
Chemistry
Topic C6 Electrochemistry, rechargeable batteries and fuel cells
Psychology
Core: Biological level of analysis
Aims:
- Aim 8: The social effects of the abuse of psychoactive drugs could be considered, as could the use of the neurotoxin Botox for cosmetic treatments.
Directly related questions
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16N.1.HL.TZ0.24:
The decline in European honeybee (Apis mellifera) populations may be linked to neonicotinoid pesticides. What effect do these pesticides have on the nervous system of insects?
A. They prevent acetylcholinesterase from breaking down acetylcholine.
B. They inhibit depolarization in the presynaptic neuron which increases the levels of acetylcholine.
C. They produce an inhibitor that promotes the binding of acetylcholine.
D. They block synaptic transmission by binding with postsynaptic acetylcholine receptors. - 17M.1.SL.TZ1.24: The diagram below shows part of the membrane of a neuron. What stage of the action potential does...
- 17M.1.SL.TZ1.21: Cladograms can be created by comparing DNA or protein sequences. The cladogram on the left is...
- 17M.1.SL.TZ1.25: Neurotransmitters are released into the synaptic cleft from the presynaptic neuron and travel to...
- 17M.1.SL.TZ2.27: The bacterium Neisseria gonorrhoeae causes infections related to the human reproductive system....
- 17M.1.SL.TZ2.29: If schizophrenia is caused by an overabundance of the neurotransmitters dopamine and serotonin in...
- 17M.1.HL.TZ2.35: What is essential for conduction of nerve impulses to be saltatory? A. Wrapping of myelin around...
- 17M.1.HL.TZ2.36: If schizophrenia is caused by an overabundance of the neurotransmitters dopamine and serotonin in...
- 17M.2.SL.TZ1.1c: Estimate how much smaller drilled oysters raised in seawater at a high CO2 concentration were...
- 17M.2.HL.TZ1.1f.ii: Suggest a reason for the greater expression of the gene for the urea transporter after an...
- 20N.1.SL.TZ0.29: How do neonicotinoid pesticides cause paralysis and death in insects? I. Acetylcholine receptors...
- 20N.2.SL.TZ0.3b.ii: X indicates the movement of a structure in the neuron. Explain what events trigger this movement...
- 20N.2.SL.TZ0.3b.i: State the name of the structure shown.
- 20N.2.HL.TZ0.2c.ii: X indicates the movement of a structure in the neuron. Explain what events trigger this movement...
- 20N.2.HL.TZ0.2c.i: State the name of the structure shown.
- 20N.1.HL.TZ0.25: The graph shows the changing membrane potential during a nerve impulse. Which letter indicates...
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17N.1.SL.TZ0.28:
Which structure in the motor neuron is required for saltatory conduction?
[Source: https://commons.wikimedia.org/wiki/File:Anatomy_and_physiology_of_animals_Motor_neuron.jpg]
- 17N.1.HL.TZ0.24: What happens when an action potential reaches motor end plates? A. Calcium ions are absorbed by...
- 21M.1.HL.TZ1.22: Which statement applies to an axon at rest? A. There is no electric potential difference between...
- 21M.1.HL.TZ1.23: Which structural feature enables saltatory conduction? A. Nodes of Ranvier between Schwann...
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21M.1.HL.TZ2.24:
The electron micrograph shows a transverse section through a myelinated neuron.
[Source: Transmission electron micrograph of a myelinated axon. https://commons.wikimedia.org/wiki/File:Myelinated_neuron.jpg. This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license (https://creativecommons.org/licenses/by-sa/3.0/deed.en).]
What process is facilitated by the presence of the structure labelled X?
A. Repolarization of the nerve cell membrane
B. Generation of an action potential
C. Saltatory conduction
D. Synaptic transmission
- 21M.2.SL.TZ1.4b: Outline the role of the sodium–potassium pump in maintaining the resting potential.
- 21M.2.SL.TZ1.4a: Estimate the resting potential for this axon.
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21M.2.SL.TZ2.1g:
Explain how neonicotinoids affect synaptic transmission in insects.
-
21M.2.SL.TZ2.1h:
Companies that manufacture neonicotinoid pesticides have argued that they do not cause significant harm to honeybees. Construct an argument, based on the data in this question, for serious concern about the manufacture and use of neonicotinoid pesticides.
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21M.2.HL.TZ2.2d.i:
State the action of the enzyme acetylcholinesterase.
- 21M.2.HL.TZ2.2a.i: On the diagrams, label with a letter H the hydrophilic end of a phospholipid.
- 21M.2.HL.TZ2.2a.ii: On the diagrams, label with a letter E a vesicle involved in exocytosis.
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21M.2.HL.TZ2.2c:
Explain how acetylcholine initiates an action potential in a postsynaptic membrane.
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21M.2.HL.TZ1.6c:
Compare and contrast hormonal and nervous communication.
- 21M.2.HL.TZ2.2a.iii: On the diagrams, label with a letter P a location where a neonicotinoid pesticide could bind.
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21M.2.HL.TZ2.2b:
Outline how depolarization of the membrane of an axon occurs.
- 21N.1.SL.TZ0.28: The graph shows changes in the membrane potential in an action potential. What is the...
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21N.2.HL.TZ0.3c:
Explain the propagation of nerve impulses along the membrane of a neuron.
- 22M.2.SL.TZ2.1a.ii: State the cumulative increase in the mass of control colonies at 7 weeks.
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22M.2.SL.TZ1.5b:
Y is the threshold potential. State what happens when the threshold potential is reached.
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22M.2.SL.TZ2.1a.i:
Describe the effect of neonicotinoid pesticides on the nervous system of insects.
-
22M.2.SL.TZ1.5c:
Describe the movements in ions that occur during time t.
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22M.2.SL.TZ2.1a.iii:
Compare and contrast the cumulative increase in mass of the three groups of colonies once they were placed in the field.
-
22M.2.SL.TZ2.1b:
Using the data in the graph, predict how the use of neonicotinoid pesticides will affect bumblebee populations.
-
22M.2.SL.TZ1.5a:
State the approximate value of the membrane potential at X.
- 22M.2.SL.TZ2.1c.i: Identify the species whose eggs are most affected by a high dose of neonicotinoid.
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22M.2.SL.TZ2.1c.ii:
Describe the overall effects of low and high doses of neonicotinoid on the egg lengths of all four species.
-
22M.2.SL.TZ1.5d:
Explain how a nerve impulse is passed on to other neurons.
- 22M.2.SL.TZ2.1a.iv: Suggest a reason for the changes in mass in the colonies between weeks 6 and 8.
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22M.2.SL.TZ2.1d:
Deduce, based on the data presented, whether the levels of neonicotinoids used in agriculture cause direct harm to B. terrestris.
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22M.1.SL.TZ2.28:
The diagram shows the synaptic transmission of nerve impulses by the neurotransmitter acetylcholine.
[Source: Zhang, X. A Mathematical Model of a Neuron with Synapses based on Physiology. Nat Prec (2008).
https://doi.org/10.1038/npre.2008.1703.1 available at https://www.nature.com/articles/npre.2008.1703.1
Source adapted.]What is the fate of acetylcholine immediately after binding to the receptor?
A. It is pumped into the postsynaptic neuron.
B. It diffuses into the presynaptic neuron.
C. It is broken down in the synaptic cleft.
D. It binds to another receptor in the postsynaptic neuron.
- 22M.1.SL.TZ1.28: The image shows a neuron. What is the function of X? A. Increases the speed of...
- 18N.1.SL.TZ0.28: The image shows a neuron. Which letter shows the myelin sheath?
- 18N.1.HL.TZ0.25: The diagram shows an action potential moving along a neuron. Which part of the diagram represents...
- 18M.2.SL.TZ2.5c: Explain the events that occur during a nerve impulse and how the impulse is propagated along an...
- 18M.1.HL.TZ2.36: Neurons transmit electrical impulses. Which statement describes part of this process? A. K+ ions...
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18M.1.SL.TZ1.2:
Common pesticides used by gardeners contain neonicotinoids.
[Source: © International Baccalaureate Organization 2018]
What is the effect of a neonicotinoid pesticide on the transmission of a nerve impulse between neurons in an insect?
A. It prevents the release of acetylcholine from the presynaptic membrane.
B. It widens the synaptic cleft so diffusion of acetylcholine across the gap is slower.
C. It irreversibly binds with acetylcholine receptors on the postsynaptic membrane.
D. It interferes with the enzymatic breakdown of acetylcholine by acetylcholinesterase.
- 18M.1.SL.TZ1.3: How does potassium move across the membrane of a neuron during repolarization? A. Simple...
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18M.2.HL.TZ1.6b:
Outline how neurons generate a resting potential.
- 18M.1.SL.TZ2.29: What process is blocked by neonicotinoid pesticides in insects? A. Transmission of the nerve...
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19M.1.SL.TZ1.29:
The diagram shows a graph of an action potential.
[Source: https://www.ncbi.nlm.nih.gov/books/NBK538143/figure/article-17127.image.f1/?report=objectonly
Physiology, Action Potential by Michael H. Grider and Carolyn S. Glaubensklee.
Copyright © 2019, StatPearls Publishing LLC
https://creativecommons.org/licenses/by/4.0/]What is happening at X?
A. Sodium channels close.
B. Calcium channels open.
C. Sodium channels open.
D. Potassium channels close.
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19M.1.HL.TZ1.24:
The diagram shows a neural synapse in the central nervous system of a honey bee (Apis mellifera).
[Source: © International Baccalaureate Organization 2019]
How do neonicotinoid pesticides cause paralysis and death of honey bees?
A. They destroy I.
B. They bind to II.
C. They inhibit the release of III.
D. They block the activity of IV.
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19M.2.SL.TZ2.1b:
Using evidence from the chart, identify, giving a reason, which group of neurons responded most to the chemicals.
- 19M.2.SL.TZ2.1e: Compare and contrast the effects of the mouse alarm compound and stoat scent on the G1 neurons.
- 19M.2.SL.TZ2.1g: The molecular structures of the mouse alarm compound and fox scent are very similar. Suggest an...
- 19M.2.SL.TZ2.1c: State the name of the instrument used to make these traces.
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19M.1.SL.TZ2.28:
The diagram shows a motor neuron.
[Source: © International Baccalaureate Organization 2019]
What are the biochemical nature and function of the myelin sheath?
A. The myelin sheath is mainly protein which allows growth of the axon.
B. The myelin sheath is mainly protein which acts as membrane carriers.
C. The myelin sheath is mainly lipid which allows saltatory conduction.
D. The myelin sheath is mainly lipid which provides an energy source.
- 19M.2.SL.TZ2.1a: State the percentage of G2 neurons in the mice that respond to the fox scent. . . . . . . . . ....
- 19M.2.SL.TZ2.1d: Distinguish between the effects of the mouse alarm compound and the effects of the control...
- 19M.2.SL.TZ2.1f: Deduce whether there is a correlation between the neural traces and the percentage of responding...
- 19N.1.SL.TZ0.28: The graph shows an action potential. What is the threshold potential for this cell? A. –80...