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2.4 Proteins

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Description

Nature of science:
Looking for patterns, trends and discrepancies—most but not all organisms assemble proteins from the same amino acids. (3.1)
Understandings:
  • Amino acids are linked together by condensation to form polypeptides.
  • There are 20 different amino acids in polypeptides synthesized on ribosomes.
  • Amino acids can be linked together in any sequence giving a huge range of possible polypeptides.
  • The amino acid sequence of polypeptides is coded for by genes.
  • A protein may consist of a single polypeptide or more than one polypeptide linked together.
  • The amino acid sequence determines the three-dimensional conformation of a protein.
  • Living organisms synthesize many different proteins with a wide range of functions.
  • Every individual has a unique proteome.
Applications and skills:
  • Application: Rubisco, insulin, immunoglobulins, rhodopsin, collagen and spider silk as examples of the range of protein functions.
  • Application: Denaturation of proteins by heat or by deviation of pH from the optimum.
  • Skill: Drawing molecular diagrams to show the formation of a peptide bond.
Guidance:
  • The detailed structure of the six proteins selected to illustrate the functions of proteins is not needed.
  • Egg white or albumin solutions can be used in denaturation experiments.
  • Students should know that most organisms use the same 20 amino acids in the same genetic code although there are some exceptions. Specific examples could be used for illustration.
Utilization:
  • Proteomics and the production of proteins by cells cultured in fermenters offer many opportunities for the food, pharmaceutical and other industries.
Aims:
  • Aim 7: ICT can be used for molecular visualization of the structure of proteins.
  • Aim 8: Obtaining samples of human blood for immunological, pharmaceutical and anthropological studies is an international endeavour with many ethical issues.

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