Outline one way in which genetic sequences can be used to indicate predisposition to a disease.

Outline the use of luminescent probes in the treatment of tumours.

a. genetic markers/specific sequences can be present in people with a disease  OWTTE

b. presence «of markers/specific sequences» indicates risk/probability of onset of condition Allow vice versa.

c. technique to detect the presence of the sequence  eg: PCR, electrophoresis, DNA sequencing, FISH, DNA databases, etc.

d. example of predisposition eg: BRCA sequence mutations indicating predisposition to breast cancer

a. transferrin/other protein taken up at higher rates by tumour cells 

b. transferrin/other protein can be labelled with a luminescent dye 

c. different tumour cell types can be distinguished/labelled in different colours 

d. can be used to highlight tumours «during surgery» OWTTE